Titlebook: Drug Resistance; William N. Hait Book 1996 Kluwer Academic Publishers 1996 DNA.Drogen.apoptosis.breast cancer.cancer.chemotherapy.drug.dru

polysomnography

书目名称Drug Resistance影响因子(影响力)




书目名称Drug Resistance影响因子(影响力)学科排名




书目名称Drug Resistance网络公开度




书目名称Drug Resistance网络公开度学科排名




书目名称Drug Resistance被引频次




书目名称Drug Resistance被引频次学科排名




书目名称Drug Resistance年度引用




书目名称Drug Resistance年度引用学科排名




书目名称Drug Resistance读者反馈




书目名称Drug Resistance读者反馈学科排名

debble

Multidrug Resistance Associated with Overexpression of MRP of tumors, such as non-small cell lung carcinomas, this resistance is inherent, while in others (e.g., acute myelogenous leukemia) it is acquired during treatment. The problem of drug resistance has been studied in the laboratory primarily by using drug-selected, cultured tumor cell lines as model

Indict

Mechanisms of Resistance to Alkylating Agentse result of the induction of a variety of protective mechanisms or the result of the selection of resistant clones. In some cases, neoplastic cells may also have a high intrinsic level of resistance [2]. Alkylating agents, particularly agents that alkylate preferentially at the O6 position of guanin

提升

Glutathione S-Transferaseschemoprotectant. In the human, levels of GSH range from 30μM in plasma to 3mM in kidney proximal tubules; tumors of various organs can contain up to 10mM GSH [1]. GSH is synthesized via the γ-glutamyl cycle (Figure 4–1). The rate-limiting step is catalyzed by γ-glutamylcysteine synthetase (γ-GCS) to

容易做

Role of DNA Repair in Resistance to Drugs that Alkylate O6 of Guaninents includes the methylating agents, temozolomide, procarbazine, dacarbazine (DTIC), and steptozotocin, and the chloroethylating agents, carmustine (1,3 bis-chloroethyl 2-nitrosourea, BCNU), lomustine (3-cyclohexyl-1-chloroethyl-nitrosourea, CCNU), (2-chloroethyl)-3-sarcosinamide-1-nitrosourea (SarC

nerve-sparing

nerve-sparing

鞭子

CRASS

显赫的人

Cellular Resistance to Topoisomerase Poisonstous in nature and are required for the regulation of DNA structure (topology) in the cell. Specifically, DNA topoisomerases regulate the coiling of the DNA double helix, a parameter critical for processes such as replication and transcription. Topoisomerases alter DNA coiling by transiently cleavin