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Titlebook: Drug Metabolite Isolation and Determination; Eric Reid,J. P. Leppard Book 1983 Plenum Press, New York 1983 carboxylic acid.chromatography.

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发表于 2025-3-21 18:50:51 | 显示全部楼层 |阅读模式
书目名称Drug Metabolite Isolation and Determination
编辑Eric Reid,J. P. Leppard
视频video
丛书名称Methodological Surveys in Biochemistry and Analysis
图书封面Titlebook: Drug Metabolite Isolation and Determination;  Eric Reid,J. P. Leppard Book 1983 Plenum Press, New York 1983 carboxylic acid.chromatography.
描述Scope of the book, and acknowledgements.- The articles are focused on ‘real problems‘ in body-fluid analysis, typically with a final chromatographic separation of ~g or often ng amounts if the aim is quantitation. The pitfalls may not be realized by a typical chemist (cf. remarks in #A-3), but he may excel in metabolite iden­ tification - which this book covers to a fair extent. Where identity is known, and the metabolite could interfere in therapeutic drug monitoring or in diagnosis or itself have clinical relevance, useful guidance will come from articles that follow. Authors have gone to much trouble, and are not to be blamed by any reader who would have liked an introduction to chromatography or to metabolic pathways (cf. list of conjugation reactions at end of concluding article). Appre­ ciation is also expressed for permission to reproduce published mat­ erial; the acknowledged sources include 1. Chroma tog. (Elsevier; e. g. in #A-l) , Anal. Chem. (American Chemical Society; #A-2) and Wiley.
出版日期Book 1983
关键词carboxylic acid; chromatography; diagnosis; phenol; reactions; society
版次1
doihttps://doi.org/10.1007/978-1-4684-4484-1
isbn_softcover978-1-4684-4486-5
isbn_ebook978-1-4684-4484-1
copyrightPlenum Press, New York 1983
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发表于 2025-3-21 22:49:25 | 显示全部楼层
of conjugation reactions at end of concluding article). Appre­ ciation is also expressed for permission to reproduce published mat­ erial; the acknowledged sources include 1. Chroma tog. (Elsevier; e. g. in #A-l) , Anal. Chem. (American Chemical Society; #A-2) and Wiley.978-1-4684-4486-5978-1-4684-4484-1
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A Novel Use of RIA and HPLC in the Identification of Plasma Metabolites of HR 158tabolites. The latter was used on eluate fractions in an HPLC system capable of separating the known and putative metabolites in human plasma. The resulting RIA-chromatogram allowed identification at ng/ml level.
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Book 1983eparation of ~g or often ng amounts if the aim is quantitation. The pitfalls may not be realized by a typical chemist (cf. remarks in #A-3), but he may excel in metabolite iden­ tification - which this book covers to a fair extent. Where identity is known, and the metabolite could interfere in thera
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https://doi.org/10.1007/b138974of these columns and of their use in examining urinary constituents (human, rat) and in metabolic work with compounds related to catecholamines. When measuring previously unauthenticated compounds, identities must be confirmed by independent means because some of the numerous urinary constituents may interfere.
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Visual Content Processing and Representationh a large range of particle sizes. It is essential to remove the finer particles, since they drastically reduce the flow rate through an alumina column. The traditional way [1] entailing washing with water is inefficient as it removes little more than colloidal material, and is very-time consuming.
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Basic Steps in Vascular Reconstructionsthe most suitable analytical methods for monitoring exposure. These typically entail GC-ECD, and their development is in general based on a common major urinary metabolite or on the pesticide itself. Dose-excretion studies enable assays to be made on manufacturing operatives, formulators and sprayers.
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