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Titlebook: Drug Discovery and Evaluation: Pharmacological Assays; Franz J. Hock Reference work 2016Latest edition Springer International Publishing S

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Methods to Induce Experimental Hypertensione by activation of the renin–angiotensin system. The principle can be used both for acute and chronic hypertension. In rats acute renal hypertension is induced by clamping the left renal artery for 4 h. After reopening of the vessel, accumulated renin is released into circulation. The protease renin
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Coronary Drugspharmacological studies (Krayer 1931; Krayer and Mendez 1942; Somani and Blum 1966; Takeda et al. 1973; Ishikawa et al. 1978, 1983; Ono and O’Hara 1984; Ono et al. 1984; Caffrey et al. 1986; Hausknecht et al. 1986; Fessler et al. 1988; Seifen et al. 1987, 1988; Naka et al. 1989). More recently, the
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Calcium Uptake Inhibition Activityhe term calcium antagonist was introduced by Fleckenstein (1964, 1967) when two drugs, prenylamine and verapamil, originally found as coronary dilators in the Langendorff experiment, were shown to mimic the cardiac effects of simple Ca. withdrawal, diminishing Ca.-dependent high-energy phosphate uti
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Positive Inotropic Activity (Cardiac Glycosides)des. They were standardized in units of an international standard. Some of the pharmacological methods used for these purposes and adopted by many pharmacopoeias have nowadays . only. This holds true for the frog method and the pigeon method (Burn et al. 1950).
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Effects on Blood Supply and on Arterial and Venous Tonus without posterior communicating artery and a frequently rudimentary anterior communicating artery. Clamping of both carotid arteries induces a bilateral temporary brain ischemia (Levine and Sohn 1969; Bosma et al. 1981; Mršulja et al. 1983; Hossman et al. 1983; Chandler et al. 1985). This pathologi
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