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Titlebook: Drug Discovery and Evaluation: Pharmacological Assays; Franz J. Hock Reference work 2016Latest edition Springer International Publishing S

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Valutazione e gestione della violenzahe term calcium antagonist was introduced by Fleckenstein (1964, 1967) when two drugs, prenylamine and verapamil, originally found as coronary dilators in the Langendorff experiment, were shown to mimic the cardiac effects of simple Ca. withdrawal, diminishing Ca.-dependent high-energy phosphate uti
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De opbouw van het bewegingsapparaat,es are encoded by at least 28 channel subunit genes (Clapham 2003; Moran et al. 2004; Clapham et al. 2005). Six protein families comprise the mammalian TRP superfamily: the classic TRPs (TRPCs), the vanilloid receptor TRPs (TRPVs), the melastatin or long TRPs (TRPMs), the mucolipins (TRPMLs), the po
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Voetdiagnostiek theorie en praktijkmethod of observing the function of individual ionic channels in a variety of normal and pathological cell types. By the use of variations of the basic recording methodology, cellular function and regulation can be studied at a molecular level by observing currents through individual ionic channels
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Voetdiagnostiek theorie en praktijkhe amplitude and duration of responses triggered by the second messengers cAMP and cGMP. The enzyme phosphodiesterase (PDE) exists in various forms. At least 11 families of phosphodiesterases have been identified (Torphy and Page 2000; Francis et al. 2001; Maurice et al. 2003; Lugnier 2006). The pro
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T. A. Grieger,D. M. Benedek,R. J. Ursanodes. They were standardized in units of an international standard. Some of the pharmacological methods used for these purposes and adopted by many pharmacopoeias have nowadays . only. This holds true for the frog method and the pigeon method (Burn et al. 1950).
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