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Titlebook: Drug Discovery and Evaluation: Pharmacological Assays; Franz J. Hock Reference work 2016Latest edition Springer International Publishing S

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Disturbi somatoformi e dissociativis induced by clamping the left renal artery for 4 h. After reopening of the vessel, accumulated renin is released into circulation. The protease renin catalyzes the first and rate-limiting step in the formation of angiotensin II leading to acute hypertension. The test is used to evaluate antihypertensive activities of drugs.
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Schede aggiuntive al primo volume,4; Ono et al. 1984; Caffrey et al. 1986; Hausknecht et al. 1986; Fessler et al. 1988; Seifen et al. 1987, 1988; Naka et al. 1989). More recently, the rat model has been preferred (Dietz 1984, 1987; Onwochei et al. 1987; Onwochei and Rapp 1988; Kashimoto et al. 1987, 1990, 1994, 1995; Fukuse et al. 1995).
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Na+/H+ Exchangegel 1998). Six mammalian Na./H. exchangers, NHE1, NHE2, NHE3, NHE4, NHE5 (Attaphitaya et al. 1999; Szabo et al. 2000), and NHE6, have been described (Tse et al. 1994; Orlowski 1999; Counillon and Pouysségur 2000).
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Methods to Induce Experimental Hypertensions induced by clamping the left renal artery for 4 h. After reopening of the vessel, accumulated renin is released into circulation. The protease renin catalyzes the first and rate-limiting step in the formation of angiotensin II leading to acute hypertension. The test is used to evaluate antihypertensive activities of drugs.
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Phosphodiesterases and the Effects of Forskolint least 11 families of phosphodiesterases have been identified (Torphy and Page 2000; Francis et al. 2001; Maurice et al. 2003; Lugnier 2006). The properties and functions of GAF domains in cyclic nucleotide phosphodiesterases are reviewed by Zoraghi et al. (2004).
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