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Titlebook: Discoidin Domain Receptors in Health and Disease; Rafael Fridman,Paul H. Huang Book 2016 Springer Science+Business Media New York 2016 can

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ignaling networks in cancer cells activated by the extracellThe interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a
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Staging the Slums, Slumming the Stagees. Accumulated data indicate that the action of DDRs in various cell types have both cell-intrinsic roles as well as affecting the nature of the extracellular matrix produced or present in pathologic conditions.
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https://doi.org/10.1007/978-3-322-94744-4nhibitors have been discovered in recent years. This chapter will provide an updated overview on the chemical structures, mechanism of action (MOA), and potential medical implications of the newly identified DDR small molecule inhibitors.
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DDRs: Binding Properties, Cell Adhesion and Modulation of Integrin Function are characterized by the presence of a discoidin homology (DS) domain in their extracellular regions, as well as a domain of similar structure, the DS-like domain. The DDRs function as transmembrane collagen receptors and are thus at the interface of receptor tyrosine kinases and integrins, the mai
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