| 书目名称 | Discoidin Domain Receptors in Health and Disease | | 编辑 | Rafael Fridman,Paul H. Huang | | 视频video | | | 概述 | Provides critical reviews of an unexplored area of research focused on a unique set of RTKs that signal in response to collagen.Elucidates signaling networks in cancer cells activated by the extracell | | 图书封面 |  | | 描述 | The interactions of cells with their surrounding extracellular matrix (ECM) plays a pivotal role in driving normal cell behavior, from development to tissue differentiation and function. At the cellular level, organ homeostasis depends on a productive communication between cells and ECM, which eventually leads to the normal phenotypic repertoire that characterize each cell type in the organism. A failure to establish these normal interactions and to interpret the cues emanating from the ECM is one of the major causes in abnormal development and the pathogenesis of multiple diseases. To recognize and act upon the biophysical signals that are generated by the cross talk between cells and ECM, the cells developed specific receptors, among them a unique set of receptor tyrosine kinases (RTKs), known as the Discoidin Domain Receptors (DDRs). The DDRs are the only RTKs that specifically bind to and are activated by collagen, a major protein component of the ECM. Hence, the DDRs are part of the signaling networks that translate information from the ECM, and thus they are key regulators of cell-matrix interactions. Under physiological conditions, DDRs control cell and tissue homeostasis b | | 出版日期 | Book 2016 | | 关键词 | cancer migration; cell signaling; collagen; extracellular matrix; receptor tyrosine kinases | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4939-6383-6 | | isbn_softcover | 978-1-4939-8182-3 | | isbn_ebook | 978-1-4939-6383-6 | | copyright | Springer Science+Business Media New York 2016 |
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发表于 2025-3-21 16:40:47
