Titlebook: Direct Mechanisms in Cholesterol Modulation of Protein Function; Avia Rosenhouse-Dantsker,Anna N. Bukiya Book 2019 The Editor(s) (if appli

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Cholesterol as a Key Molecule That Regulates TRPV1 Channel Functionntrol pain. To date, several activators and positive modulators of the activity of TRPV1 have been described. However, very few naturally-occurring inhibitors are known. An endogenously-produced molecule that inhibits the activity of TRPV1 is cholesterol. This chapter focuses on describing the mecha

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https://doi.org/10.1057/9780230600751ane domains. The interactions between cholesterol and the protein in both cases critically depends on hydrophobic and aromatic residues. In addition, cholesterol binding sites in both types of domains involve polar and/or charged residues. However, the percentage of appearance of the different types

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She Got Game, but She Don’t Got Fameh allows us to systematically assess the flexibility and variability of cholesterols in transmembrane proteins. Together, this joint analysis reveals the common characteristics among the observed cholesterol structures, thereby offering important guidelines for prediction and modification of potenti

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Kleingedrucktes ganz groß geschriebensterol whereas Kir3.2^ and Kir3.4* were both up-regulated by cholesterol. Despite the opposite impact of cholesterol on these Kir3 channels compared to Kir2.1, putative cholesterol binding sites in all three channels were identified in equivalent transmembrane domains. Interestingly, however, there