Titlebook: Direct Mechanisms in Cholesterol Modulation of Protein Function; Avia Rosenhouse-Dantsker,Anna N. Bukiya Book 2019 The Editor(s) (if appli

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Cholesterol-Recognition Motifs in Membrane Proteinsng these effects have remained elusive. There appear to be multiple mechanisms by which cholesterol interacts with proteins. A complete understanding of cholesterol-sensing motifs is still undergoing refinement. Initially, cholesterol was thought to exert only non-specific effects on membrane fluidi

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Crystallographic Studies of Steroid-Protein Interactionsand intracellular signaling. X-ray crystallography has served as a successful tool for gaining understanding of the structural and mechanistic aspects of these functions by providing snapshots of steroids in complex with various types of proteins. These proteins include nuclear receptors activated b

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Cholesterol as a Key Molecule That Regulates TRPV1 Channel Function channels, are molecules inserted in cell membranes and their activity is regulated by cholesterol and other molecules of a lipidic nature present in them. The molecular mechanisms underlying the regulation of ion channels by lipids and similar molecules have been an object of study for several year

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Cholesterol Binding Sites in Inwardly Rectifying Potassium Channelsocytes and muscle cells, and setting the resting membrane potential, heart rate, vascular tone, insulin release, and salt flow across epithelia. These processes are regulated by a variegated list of modulators. In particular, in recent years, cholesterol has been shown to modulate a growing number o

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Insights into the Molecular Mechanisms of Cholesterol Binding to the NPC1 and NPC2 Proteinserol. Our current understanding of this process developed with just over two decades of research. Since the cloning of the genes encoding the NPC1 and NPC2 proteins, studies of the biochemical defects observed when either gene is mutated along with computational and structural studies have unraveled

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Book 2019art starts with a tour into common cholesterol recognition motifs, followed by an overview of the major classes of steroid-binding proteins. It then continues with two chapters that present a comprehensive analysis of molecular and structural characteristics of cholesterol binding sites in transmemb