| 书目名称 | Direct Mechanisms in Cholesterol Modulation of Protein Function |
| 编辑 | Avia Rosenhouse-Dantsker,Anna N. Bukiya |
| 视频video | |
| 概述 | Very timely topic as cholesterol, increasingly, has been implicated as a major regulator of protein function.Contributors are well-known experts in their fields and provide international perspective.R |
| 丛书名称 | Advances in Experimental Medicine and Biology |
| 图书封面 |  |
| 描述 | .In this book, renowned scientists describe how cholesterol interacts with various proteins. Recent progress made in the high-resolution visualization of cholesterol-protein interactions using crystallography and cryogenic electron microscopy has substantially advanced the knowledge of critical features. These features enable specific recognition of the cholesterol molecule by proteins, a process that was built on earlier studies using binding assays, computational modeling and site-directed mutagenesis. .Direct Mechanisms in Cholesterol Modulation of Protein Function .offers comprehensive insights into the current understanding of cholesterol-driven modulation of protein function via direct sensing. Its nine chapters are organized into two distinct parts. In the first part, the chapters introduce the reader to the general characteristics of cholesterol binding sites in proteins. This part starts with a tour into common cholesterol recognition motifs, followed by an overview of the major classes of steroid-binding proteins. It then continues with two chapters that present a comprehensive analysis of molecular and structural characteristics of cholesterol binding sites in transmemb |
| 出版日期 | Book 2019 |
| 关键词 | cholesterol modulation; protein function; cholesterol binding; steroid-protein interaction; lipid membra |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-3-030-14265-0 |
| isbn_softcover | 978-3-030-14267-4 |
| isbn_ebook | 978-3-030-14265-0Series ISSN 0065-2598 Series E-ISSN 2214-8019 |
| issn_series | 0065-2598 |
| copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerl |
发表于 2025-3-21 19:09:48
