Titlebook: Diabetes Mellitus; A risk factor for Al Yusaku Nakabeppu,Toshiharu Ninomiya Book 2019 Springer Nature Singapore Pte Ltd. 2019 Brain-derived

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Advances in Experimental Medicine and Biologyhttp://image.papertrans.cn/d/image/270404.jpg

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https://doi.org/10.1007/978-981-13-3540-2Brain-derived insulin; Default network; Glucose/energy metabolism; Mitochondrial dysfunction; Oxidative

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Springer Nature Singapore Pte Ltd. 2019

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,Type II Diabetes Mellitus Accelerates Age-Dependent Aβ Pathology in Cynomolgus Monkey Brain, as intraneuronal accumulation of enlarged endosomes, was exacerbated in T2DM-affected monkey brains. Since accumulating evidences suggest that endocytic dysfunction is involved in Aβ pathology, T2DM may aggravate age-related endocytic dysfunction, leading to the acceleration of Aβ pathology.

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