| 书目名称 | Diabetes Mellitus |
| 副标题 | A risk factor for Al |
| 编辑 | Yusaku Nakabeppu,Toshiharu Ninomiya |
| 视频video | |
| 概述 | Describes in detail the mechanisms that make diabetes mellitus a risk factor for Alzheimer’s disease (AD).Discusses the molecular interactions between diabetes and AD.Gives deep insights into AD treat |
| 丛书名称 | Advances in Experimental Medicine and Biology |
| 图书封面 |  |
| 描述 | .This book describes the precise mechanisms by which insulin resistance and diabetes mellitus (DM) act as risk factors for Alzheimer’s disease (AD). It opens by discussing the de novo synthesis of insulin in the brain and its functional significance with regard to glucose metabolism and maintenance of neuronal function in the brain. The epidemiological evidence that DM is a risk factor for the development of dementia, including AD as well as vascular dementia, is then examined. Subsequent chapters explore in depth the mechanisms involved in this relationship, including abnormal protein processing, dysregulated glucose metabolism, impaired insulin signaling, and mitochondrial dysfunction. The molecular interactions between diabetes and AD are fully discussed, highlighting the pathological molecular mechanisms induced by diabetes that promote and accelerate AD pathology. Finally, diagnostic biomarkers and potential therapeutic approaches for AD are considered on the basis of the presented evidence. In providing answers to the critical questions of whether and why DM is a risk factor for AD, this book will hold appeal for a wide interdisciplinary audience. . |
| 出版日期 | Book 2019 |
| 关键词 | Brain-derived insulin; Default network; Glucose/energy metabolism; Mitochondrial dysfunction; Oxidative |
| 版次 | 1 |
| doi | https://doi.org/10.1007/978-981-13-3540-2 |
| isbn_ebook | 978-981-13-3540-2Series ISSN 0065-2598 Series E-ISSN 2214-8019 |
| issn_series | 0065-2598 |
| copyright | Springer Nature Singapore Pte Ltd. 2019 |
发表于 2025-3-21 16:03:44
