Titlebook: Dendritic Cells in Cancer; Russell D. Salter,Michael R. Shurin Book 2009 Springer-Verlag New York 2009 Activation.Cancer.Dendritic Cells.D

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Changes in Dendritic Cells in Cancer and Agingosts exhibit significant functional defects at multiple levels. These changes may provide a mechanistic basis for the disappointing results of dendritic cell-based immunotherapy in older cancer patients. There is clearly a need to improve our knowledge on how aging modulates these parameters to optimally exploit DC in anticancer vaccines.

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https://doi.org/10.1007/978-3-642-80376-5is or interfere with antigen presentation. Identifying those molecules and their interaction with dendritic cells will accelerate the development of more efficient immunotherapies. In this chapter we review the current literature on these interactions and highlight the possible avenues of minimization of their deleterious effects.

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