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Titlebook: Dendritic Cells in Cancer; Russell D. Salter,Michael R. Shurin Book 2009 Springer-Verlag New York 2009 Activation.Cancer.Dendritic Cells.D

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书目名称Dendritic Cells in Cancer
编辑Russell D. Salter,Michael R. Shurin
视频video
概述Presents the very first analysis of published and not-yet published experimental and clinical data related to the immunobiology of DC in tumor-bearing hosts.No other publication combines all issues re
图书封面Titlebook: Dendritic Cells in Cancer;  Russell D. Salter,Michael R. Shurin Book 2009 Springer-Verlag New York 2009 Activation.Cancer.Dendritic Cells.D
描述.It covers all aspects of DC generation, function, survival and antitumor activity in the tumor environment both in vivo and in experimental in vitro systems. The goal in focusing on a spectrum of issues related to DC in cancer is to provide an extensive and expansive review rather than a collection of independent analyses from different authors...Specific topics to be covered include analysis of DC behavior in the tumor microenvironment, including endogenous and exogenous DC, multiple DC populations, molecular pathways responsible for DC dysfunction, tumor-derived factors altering DC polarization and activation, mechanisms of DC alterations, and the role of DC in tumor escape from immune recognition and elimination. Furthermore, additional chapters provide extensive analysis of the consequences of cancer therapy on the DC system and how aging impacts DC function in the tumor microenvironment. Finally, chapters are included examining strengths and pitfalls of current methodologies for generating DC from cancer patients for therapeutic purposes and on the role of tumor-mediated modulation of the DC system in cancer immunotherapy..
出版日期Book 2009
关键词Activation; Cancer; Dendritic Cells; Dendritic cell vaccines; Endoplasmatisches Reticulum; IDO; Promoter; R
版次1
doihttps://doi.org/10.1007/978-0-387-88611-4
isbn_softcover978-1-4419-2784-2
isbn_ebook978-0-387-88611-4
copyrightSpringer-Verlag New York 2009
The information of publication is updating

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Functional Defects of Dendritic Cells in Cancerritic cells evolve with their differentiation and are tightly controlled by the cytokine network. Tumors actively interfere with dendritic cell differentiation and their acquisition of functional properties and render them defective. This chapter reviews the data characterizing the effect of tumor o
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