Titlebook: Dendritic Cells in Cancer; Russell D. Salter,Michael R. Shurin Book 2009 Springer-Verlag New York 2009 Activation.Cancer.Dendritic Cells.D

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Tumor-Associated Inflammation and Impact on Dendritic Cell Functiont data show that inflammatory processes around malignancies are able to both support and suppress neoplastic progression depending on the phase of tumor progression or the cytokine context of ongoing immunological processes in the tumor microenvironment. Recent concepts of malignancy-associated infl

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Stress, Immunity and Dendritic Cells in Canceres and stress-associated molecules have well-documented effects on the activity of lymphocytes, stress exposure may disrupt processes that occur earlier in the immune response. Stress-induced alterations in immune function may, in part, result from changes in the development and/or function of cells

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Cancer Therapy and Dendritic Cell Immunomodulationreatment of metastatic disease, cytotoxic chemotherapy is the mainstay of treatment, although it is broadly targeted and results in toxicity to normal tissues with limited expectation of curing metastatic tumors. Immunotherapies have also been explored over several decades. Among immunotherapies, ap

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https://doi.org/10.1007/978-3-030-85825-4cal for eliciting antitumor immunity. Dendritic cells are particularly potent antigen-presenting cells due to their ability to take up, process, and present antigen to both CD4+ and CD8+ T cells. They can promote inflammation at local sites of infection and act as carriers of antigen to lymphoid org

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https://doi.org/10.1007/978-3-030-85825-4mmune-mediated inflammatory disorders, including malignant diseases. The mechanisms central to the etiology and pathogenesis of many of these chronic inflammatory conditions involve dendritic cells. Identification of dendritic cells in tumors as well as clinical evaluation of dendritic cell vaccines

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https://doi.org/10.1007/978-3-658-09282-5ritic cells evolve with their differentiation and are tightly controlled by the cytokine network. Tumors actively interfere with dendritic cell differentiation and their acquisition of functional properties and render them defective. This chapter reviews the data characterizing the effect of tumor o