Titlebook: Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy; Emmanuel Donnadieu Book 2016 Springer International Publishing Switz

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Homing Improvement: Boosting T Cell Trafficking for Cancer Immunotherapy,mmatory migration of T cells is possible by modulating any number of components in the leukocyte migration machinery, from chemo-attractants, to integrins, to extracellular matrix adhesion ligands. Promising results suggest that the homing problem can indeed be overcome to remove a major barrier in

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Chemokines and T Cell Trafficking into Tumors: Strategies to Enhance Recruitment of T Cells into Tue transferred cytotoxic T cells are providing a possible means of overcoming such obstacles. Integration of such strategies in immunotherapy protocols may hopefully pave the way to a more successful clinical application of T cell immunotherapy.

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2196-5501 that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy..978-3-319-82528-1978-3-319-42223-7Series ISSN 2196-5501 Series E-ISSN 2196-551X

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Book 2016velopment. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy..

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2196-5501 niciples to T cell migration during efficient immune responsThis volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent suc

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K. F. Leonhardt,R. v. Tiepermann,M. Dosstion, focusing on extra- and intracellular guidance cues gained primarily from intravital two photon imaging, and relate this with the efficient unfolding of adaptive immune responses. From this, we outline the challenges that T cells face entering and maneuvering inside non-lymphoid tissues including tumor sites.

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Basic Rules of T Cell Migration,tion, focusing on extra- and intracellular guidance cues gained primarily from intravital two photon imaging, and relate this with the efficient unfolding of adaptive immune responses. From this, we outline the challenges that T cells face entering and maneuvering inside non-lymphoid tissues including tumor sites.