Titlebook: DNA Vaccines; W. Mark Saltzman,Hong Shen,Janet L. Brandsma Book 2006 Humana Press 2006 Antigen.T cell.autoimmunity.cell.molecular biology.

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Boris Kovalerchuk,Kawa Nazemi,Ebad Banississional antigen-presenting cells (APCs), such as dendritic cells (DCs) play important roles in generating humoral and cell-mediated antigen-specific immune responses by DNA vaccination. Continuing progress in our understanding of how professional APCs uptake DNA, process and present the antigens enc

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DNA Vaccines978-1-59745-168-0Series ISSN 1543-1894 Series E-ISSN 1940-6037

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DNA Vaccine DesignThe purpose of this chapter is to present basic strategies for the construction of DNA vaccines. This chapter discusses considerations relevant to the selection of a target gene, construction of a DNA expression vector for use as a vaccine, and molecular modifications of the vector to improve protein expression and to augment immunogenicity.

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A Stress Protein-Facilitated Antigen Expression System for Plasmid DNA Vaccines unstable or toxic proteins (or protein domains) can be expressed. We describe the design of DNA vaccines expressing antigens with a stress protein-capturing domain and characterize the immunogenicity of the antigens produced by this expression system.

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Needle-Free Injection of DNA Vaccines: A Brief Overview and Methodologyhancing DNA vaccines. This approach requires no additional development, and with an expanding market and willingness from jet injector manufacturers to produce prefilled syringes, the technique should become feasible for larger phase II/phase III trials.

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Modifying Professional Antigen-Presenting Cells to Enhance DNA Vaccine Potencyegies to increase the numbers of antigen-expressing DCs, strategies to enhance MHC class I and/or II presentation of the encoded antigen and strategies to prolong the life of antigen-expressing DCs to enhance DNA vaccine potency. We will also discuss the methodology involved in DNA vaccine developme

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1543-1894 ne technology, with chapters describing DNA vaccine design, delivery systems, adjuvants, current appli- tions, methods of production, and quality control. Consi978-1-61737-596-5978-1-59745-168-0Series ISSN 1543-1894 Series E-ISSN 1940-6037