| 书目名称 | DNA Repair and Mutagenesis in Eukaryotes | | 编辑 | W. M. Generoso,M. D. Shelby,F. J. Serres | | 视频video | | | 丛书名称 | Basic Life Sciences | | 图书封面 |  | | 描述 | Not many years ago most discussion of mutation induction by physical and chemical agents concentrated on the initial lesions induced in the DNA with the implicit assumption that once the lesions were made they were converted almost automatically to mutations by relatively simple processes associated with DNA replication. The discovery of a variety of enzymatic processes that can repair these lesions, the great increase in our understanding of the molecular steps involved in repair, replication, and recombination, and the increasing availability of cells with genetic defects in these pro cesses have led to the realization that mutation induction is a far more complex process than we originally thought. Repair systems can remove lesions before they can be converted to mutation, they can also convert initial lesions to secondary ones that are them selves mutagenic, and they can remove potentially lethal lesions at the expense of making mutations. The error-avoiding systems asso ciated with replication are themselves complex and may be caused to make mistakes in various ways. These different pathways for mutation production and mutation avoidance are still being worked out in prokar | | 出版日期 | Book 1980 | | 关键词 | DNA; cells; chromosome; mutagen; mutagenesis; mutation; production | | 版次 | 1 | | doi | https://doi.org/10.1007/978-1-4684-3842-0 | | isbn_softcover | 978-1-4684-3844-4 | | isbn_ebook | 978-1-4684-3842-0 | | copyright | Springer Science+Business Media New York 1980 |
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发表于 2025-3-21 20:07:43
