| 书目名称 | DNA Repair Protocols | | 编辑 | Daryl S. Henderson | | 视频video | http://file.papertrans.cn/261/260181/260181.mp4 | | 丛书名称 | Methods in Molecular Biology | | 图书封面 |  | | 描述 | The field of eukaryotic DNA repair is enjoying a period of remarkable growth and discovery, fueled by technological advances in molecular bi- ogy, protein biochemistry, and genetics. Notable achievements include the molecular cloning of multiple genes associated with classical human repair disorders, such as xeroderma pigmentosum, Cockayne syndrome, and ataxia telangiectasia; elucidation of the core reaction of nucleotide excision repair (NER); the discovery that certain NER proteins participate not only in repair, but also in transcription; recognition of the crucial role played by mismatch repair processes in maintenance of genome stability and avoidance of cancer; the findings that the tumor suppressor protein p53 is mutated in many types of cancer, and has a key role in directing potentially malignant, genotoxin-d- aged cells towards an apoptotic fate; and the discovery and elaboration of DNA damage (and replication) checkpoints, which placed repair phenomen- ogy firmly within a cell-cycle context. Of course, much remains to be learned about DNA repair. To that end, DNA Repair Protocols: Eukaryotic Systems is about the tools and techniques that have helped propel the DNA repair | | 出版日期 | Book 1999 | | 关键词 | DNA; Ligation; PCR; Quantitative PCR; cell lines; genes; saccharomyces cerevisiae | | 版次 | 1 | | doi | https://doi.org/10.1385/1592596754 | | isbn_softcover | 978-1-61737-196-7 | | isbn_ebook | 978-1-59259-675-1Series ISSN 1064-3745 Series E-ISSN 1940-6029 | | issn_series | 1064-3745 | | copyright | Humana Press 1999 |
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