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Titlebook: DNA Methylation Protocols; Ken I. Mills,Bernard H. Ramsahoye Book 20021st edition Humana Press 2002

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1064-3745 and methylases. These powerful methods provide the tools necessary for studying methylation at both the global level and the level of sequence, and include many techniques for identifying genes that might be aberrantly methylated in cancer and aging. Additional methods cover genome-wide analysis of
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Balaram Ghosal,Richard Sigliano,Y. Kunimatsuter region of housekeeping genes, in groups known as CpG islands. These short stretches of DNA have a have a C and G base composition, which in mammals and avians is estimated to be 10 times higher than in bulk DNA (.)
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Nearest-Neighbor Analysis,CpG dinucleotides. It has the added advantage of being applicable to small samples of the order of 1 microgram of genomic DNA. The only drawback is that it is a radioactive technique and the appropriate facilities and techniques for handling radioactive substances must be available.
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