Titlebook: DNA Helicases and DNA Motor Proteins; Maria Spies Book 2013 The Editor(s) (if applicable) and The Author(s), under exclusive license to Sp

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Book 2013icases and related molecular motors. By integrating the knowledge obtained through the diverse technical approaches ranging from single-molecule biophysics to cellular and molecular biological studies the editors aim to provide a unified view on how helicases function in the cell, are regulated in r

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https://doi.org/10.1007/978-3-8348-8620-0g strand maturation and termination of replication all depend on helicases. Moreover, if disaster strikes and a replication fork breaks down then reloading of the replication machinery is effected by helicases, at least in bacteria. This chapter describes how helicases function in these multiple ste

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https://doi.org/10.1007/978-3-8348-8620-0-­resistance among mutants already shows subtle differences between compounds in this respect. The impact of resistance on the drug development in the clinic will also be considered. Finally, herpesvirus latency remains as the most important barrier to a therapeutic cure. Whether or not helicase pri

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https://doi.org/10.1007/978-3-658-27654-6 outcomes are dependent upon these helicase enzymes. Since mutations in some of these helicases lead to cancer predisposition in humans and mice, studies on them have clear relevance to human health and disease.

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