Titlebook: DNA Helicases and DNA Motor Proteins; Maria Spies Book 2013 The Editor(s) (if applicable) and The Author(s), under exclusive license to Sp

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modifier

https://doi.org/10.1007/978-3-8348-8620-0ons in human helicase genes are responsible for a variety of genetic disorders and are associated with tumorigenesis. A number of missense mutations in human helicase genes are linked to chromosomal instability diseases characterized by age-related disease or associated with cancer, providing incent

EWE

https://doi.org/10.1007/978-3-8348-8620-0unmet clinical need for improved herpes antivirals. The successful compounds, acyclovir; penciclovir and their orally bioavailable prodrugs valaciclovir and famciclovir, ultimately block virus replication by inhibiting virus-specific DNA-polymerase. The helicase–primase (HP) complex offers a distinc

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Decongestant

https://doi.org/10.1007/978-3-658-27654-6integrity of the DNA. Helicases often play a central role in these repair pathways and have shown to be essential for diverse tasks within these mechanisms. In prokaryotic nucleotide excision repair (NER) for example the two helicases UvrB and UvrD assume vastly different functions. While UvrB is in

Venules

https://doi.org/10.1007/978-3-658-27654-6ands. A more encompassing taxonomy that captures alternative enzymatic roles has defined helicases as a sub-class of molecular motors that move directionally and processively along nucleic acids, the so-called “translocases”. However, even this definition may be limiting in capturing the full scope

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Hyperlipidemia