Titlebook: Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development; Proceedings of the T Frederick A. Valeriote,Thomas H. C

预感

痛打

choroid

净礼

https://doi.org/10.1007/978-3-642-73937-8se antibodies; and the uncertain efficacy of the host cell anti-tumor response (.,.). Immunoconjugates employing monoclonal antibodies as carriers for toxins, drugs, or radioisotopes and chimeric human-mouse monoclonal antibodies remain under investigation (.,.).

透明

侵略

excursion

Discovery of Solid Tumor Active Agents Using a Soft-Agar-Colony-Formation Disk-Diffusion-Assay,s needed to pass in order to advance toward clinical development (L1210 prior to 1975 and P388 after 1975). It is thus not surprising that agents in the clinic are highly active against these tumor systems. However, none of the agents discovered by these leukemias are tumor specific (i.e., active ag

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Thymidylate Synthase Inhibition of Modified Quinazoline Antifolates,o deoxythymidine monophosphate (dTMP) and represents the only de novo source of this nucleotide required for DNA synthesis. The co-factor 5, 10-methylenetetrahydrofolate (I) supplies the one-carbon fragment required for the reaction and also acts as a reducing agent. Regeneration of the co-factor is

腐烂

syncope