Titlebook: Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development; Proceedings of the T Frederick A. Valeriote,Thomas H. C

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https://doi.org/10.1007/978-3-642-73937-8tivity and water solubility. This paper reviews the preclinical antitumor activity of brequinar sodium against murine tumors and human carcinomas xenografted in nude mice, the mechanism of action of the agent, and the structure activity relationship of this class of 4-quinolinecarboxylic acids.

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Large Scale Anticancer Drug Screening at Sterling Drug Inc.,ity and possibly selectivity. Because leukemia based screens often select various structural classes with identical chemotypes, it is our opinion that screening systems geared to select those agents demonstrating selective toxicity versus solid tumors may identify new chemotypes.

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Preclinical Studies with Brequinar Sodium: A Novel Anticancer Agent,tivity and water solubility. This paper reviews the preclinical antitumor activity of brequinar sodium against murine tumors and human carcinomas xenografted in nude mice, the mechanism of action of the agent, and the structure activity relationship of this class of 4-quinolinecarboxylic acids.

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Conference proceedings 1992um including the exciting frontiers of drugdiscovery being explored by the National Cooperative Drug DiscoveryGroups (NCDDG) Program. The symposium brought together a large numberof investigators from government, universities and pharmaceuticalcompanies involved in the discovery and development of n

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https://doi.org/10.1007/978-3-642-73937-8ear in the United States alone. Despite the proven efficacy of radiotherapy in the treatment of certain tumor types, nearly one half of the patients treated with radiotherapy will die with at least microscopic recurrence of tumor at the irradiated site (.).

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https://doi.org/10.1007/978-3-642-73937-8ed at a dose of onetenth the LD. in mice. Then, human pharmacology studies are conducted to determine plasma CXT data in patients. The dose is then escalated to approach a plasma CXT equal to that achieved in the mouse model.

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