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Titlebook: Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development; Proceedings of the T Frederick A. Valeriote,Thomas H. C

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书目名称Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development
副标题Proceedings of the T
编辑Frederick A. Valeriote,Thomas H. Corbett,Laurence
视频video
丛书名称Developments in Oncology
图书封面Titlebook: Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development; Proceedings of the T Frederick A. Valeriote,Thomas H. C
描述The focus of the 22nd Annual Detroit Cancer Symposium was thepresentation and discussion of cytotoxic agents, with a significantportion of the symposium including the exciting frontiers of drugdiscovery being explored by the National Cooperative Drug DiscoveryGroups (NCDDG) Program. The symposium brought together a large numberof investigators from government, universities and pharmaceuticalcompanies involved in the discovery and development of new anticanceragents. Exciting new leads were presented and the status of otherspresently under development was discussed..Of particular significance has been the initiation of renewed effortsin the area of natural product drug discovery, where the discovery ofnew cytotoxics is very promising at the moment. A number of majorchanges have occurred during the last decade in research on drugdiscovery of cytotoxic agents. Critical reviews of a number of themodels and concepts underlying drug discovery represented a continuousthread throughout the meeting, being constantly discussed in terms oftheir advantages, disadvantages and capabilities of discovering solidtumor active anticancer agents..A recent development which is to be much applauded and
出版日期Conference proceedings 1992
关键词AIDS; DNA; drug design; hormones; radiotherapy; screening; tumor
版次1
doihttps://doi.org/10.1007/978-1-4615-3492-1
isbn_softcover978-1-4613-6548-8
isbn_ebook978-1-4615-3492-1
copyrightSpringer Science+Business Media New York 1992
The information of publication is updating

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https://doi.org/10.1007/978-3-642-73937-8itumor drug discovery screen. These efforts have not only been controversial, but have also been undertaken during an era of diminishing resources for antitumor drug screening and drug development at NCI. Moreover, numerous unanticipated obstacles, not only in the scientific and technical aspects, b
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https://doi.org/10.1007/978-3-642-73937-8s needed to pass in order to advance toward clinical development (L1210 prior to 1975 and P388 after 1975). It is thus not surprising that agents in the clinic are highly active against these tumor systems. However, none of the agents discovered by these leukemias are tumor specific (i.e., active ag
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