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Titlebook: Cytoskeleton of the Nervous System; Ralph A. Nixon,Aidong Yuan Book 2011 Springer Science+Business Media, LLC 2011

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Überwachung während der Narkosebulin polymerization and stabilizes polymerized-microtubules as do neural MAPs. Because MAP2, MAP4, and tau are structurally similar, the three MAPs are considered to constitute a superfamily. The architecture of the superfamily proteins consists of an amino-terminal projection domain and a carboxyl
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https://doi.org/10.1007/978-3-662-05721-6pecific and fully functional IF. It has been established that the IF molecule is a dimer and that its two constituent chains lie parallel to each other and in axial register. The molecule has a tripartite structure with a central, α-helical, coiled-coil–rich region (the rod domain) separating the he
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https://doi.org/10.1007/978-3-662-50444-4mately 10 nm diameter. Among intermediate filaments, NFs have unique chemical and structural properties. They are composed of three distinctly different proteins called . (NF-L, NF-M, and NF-H) and are constituted morphologically of two distinct domains in vivo: core filaments and cross-bridges late
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https://doi.org/10.1007/978-3-642-28291-1n the soma and transported into axonal and dendritic processes. Neurofilaments are transported by the process of slow axonal transport, which arises from fast transport interrupted by extended pauses. Some of the mechanisms regulating neurofilament assembly and transport have been identified. It is
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Überwachung der Herz-Kreislauf-Funktione last 15 years, the gene targeting technique has been widely used to investigate the role of NF proteins in neuronal function. Gene knockout studies have demonstrated that NFs are crucial to expand the caliber of myelinated axons and consequently to increase their conduction velocity. However, the
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Intensivbehandlung nach Herzoperationenlong the axon. Prior to the development of neurofilament gene-targeted mice, it was thought that radial growth was mediated by myelin-dependent phosphorylation of neurofilament heavy and neurofilament medium within the axon. The systematic analysis of gene-targeted mice has furthered our understandi
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Überwachung der Herz-Kreislauf-Funktionpendent kinase 5 (Cdk5), Glycogen synthase kinase 3β (GSK3β) and MAPKs have been implicated in their direct involvement in neuronal cytoskeletal protein phosphorylation. Cdk5 and GSK3β have been identified as prime candidates for pathogenesis. Cdk5 is a proline-directed serine/threonine protein kina
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