Titlebook: Cytokines, Stress, and Depression; Robert Dantzer,Emmanuelle E. Wollman,Raz Yirmiya Book 1999 The Editor(s) (if applicable) and The Author

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Anhedonic and Anxiogenic Effects of Cytokine Exposureoducts of an activated immune system, e.g., cytokines) affect neuroendocrine and central neurotransmitter processes, and conversely, neuroendocrine and central neurotransmitter alterations may impact on immune activity (Anisman, Zalcman, & Zacharko, 1993; Blalock, 1994; Dunn, 1990; Rivier, 1993; Rot

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Stress, Depression, and The Role of Cytokines200 AD, suggested that melancholic women are more susceptible to breast cancer than sanguine women (Leonard, 1987). Over the past 15 years it has become apparent that the central nervous system (CNS) and the immune system are intimately connected and that a functional bidirectional communication exi

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Kai Brodersen,Bernhard Zimmermann. A concept of an interrelationship between the immune system and the nervous system, i.e. the psychological state, has been suggested before the first studies in psychoneuroimmunology have been conducted. Several authors implicated that mood disturbances may result in an increased susceptibility to

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Kai Brodersen,Bernhard Zimmermannesis of major depression. Since the rate of major depression in genetically succeptible populations has continued to increase over the past years, the identification of these environmental factors would provide targets for more effective antidepressant agents.