Titlebook: Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism; Aparajita Dey Book 2013 Springer Science+Business Media Dordrecht 2013 Cytoc

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Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism978-94-007-5881-0Series ISSN 0306-0225 Series E-ISSN 2542-8810

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0306-0225 pplementary material: The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associate

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B. M. Tang,V. Herwanto,A. S. McLeantration of ethanol and drugs. Induction of CYP2E1 leads to prominent epigenetic effects and CYP2E1 polymorphism may be associated with alcoholic liver disease. These are some aspects of CYP2E1, amongst many others which account for its importance in the context of drug metabolism and disease development and have been reviewed in the chapter.

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A. De Jong,D. Verzilli,S. Jaber presentation, and macromolecular degradation, all of which are crucial to liver cell function and viability. Here, we describe our own and other published work relevant to the importance of CYP2E1-catalyzed ethanol oxidation and how this catalysis affects the aforementioned cellular processes to produce liver injury.

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P. Formenti,M. Brioni,D. ChiumelloYP2E1 is expressed abundantly within the microsomes of certain brain cells and is localized to particular brain regions. This chapter focuses on the discussion of CYP2E1 in ethanol metabolism in the CNS, covering topics including how it is regulated, where it is expressed and how it influences sensitivity to ethanol in the brain.

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The Role of CYP2E1 in Alcohol Metabolism and Sensitivity in the Central Nervous System,YP2E1 is expressed abundantly within the microsomes of certain brain cells and is localized to particular brain regions. This chapter focuses on the discussion of CYP2E1 in ethanol metabolism in the CNS, covering topics including how it is regulated, where it is expressed and how it influences sensitivity to ethanol in the brain.

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Book 2013al for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty l