| 书目名称 | Cytochrome P450 2E1: Its Role in Disease and Drug Metabolism | | 编辑 | Aparajita Dey | | 视频video | http://file.papertrans.cn/243/242614/242614.mp4 | | 概述 | Research overview.State of the art literature.Contributions by experts in the field.Deals extensively with mechanisms for injury.Includes supplementary material: | | 丛书名称 | Subcellular Biochemistry | | 图书封面 |  | | 描述 | The book deals with various clinical aspects of cytochrome P450 2E1 (CYP2E1) which is a potent source for oxidative stress. Oxidative stress is critical for pathogenesis of diseases and CYP2E1 is a major contributor for oxidative stress. Several clinical disorders are associated with changes in regulation of CYP2E1 and the consequent abnormalities which include alcoholic liver disease, alcoholic pancreatitis, carcinogenesis, non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, obesity, hepatitis C virus infection, reproductive organ toxicity, hepatocellular and cholestatic liver cirrhosis, inhibition of bone repair, cross-tolerance in smokers and people treated with nicotine, disorders of central nervous system, changes in metabolism of protoxicants in the circulatory system and susceptibility to human papillomavirus infection. Hence, CYP2E1 emerges as a new and potent player in aggravating injury and furthering disease complications. | | 出版日期 | Book 2013 | | 关键词 | Cytochrome P4502E1; diseases; drugs; injury; reactive oxygen species | | 版次 | 1 | | doi | https://doi.org/10.1007/978-94-007-5881-0 | | isbn_softcover | 978-94-017-8202-9 | | isbn_ebook | 978-94-007-5881-0Series ISSN 0306-0225 Series E-ISSN 2542-8810 | | issn_series | 0306-0225 | | copyright | Springer Science+Business Media Dordrecht 2013 |
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