Titlebook: Cyclin-Dependent Kinase (CDK) Inhibitors; Methods and Protocol Mar Orzáez,Mónica Sancho Medina,Enrique Pérez-Payá Book 2016 Springer Scienc

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Assessing Cell Cycle Independent Function of the CDK Inhibitor p21CDKN1A in DNA Repair, activity of CDK inhibitor. In addition to cell cycle, this protein regulates cell transcription, apoptosis, cell motility, and DNA repair. In particular, p21 may participate in different DNA repair processes, like the nucleotide excision repair (NER), base excision repair (BER), and double-strand b

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Drug Delivery Strategies of Chemical CDK Inhibitors,are not an exception. Nanotechnology may be able to solve some of the main problems limiting cancer treatments such as more specific delivery of therapeutics and reduction of toxic secondary effects. It provides new delivery systems able to specifically target cancer cells and release the active mol

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Evaluating Chemical CDK Inhibitors as Cell Death Inducers,tion and biological characterization of a highly potent, small-molecule pan-Cdk inhibitor, which inhibited Cdk1, 2, 4, 5, 6, and 9 with equal potency in the nM range. This compound inhibited multiple events in the cell cycle and induced cell death in human cancer cell lines as well as in peripheral

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Models for the Study of the Cross Talk Between Inflammation and Cell Cycle,tional activity via phosphorylation of RNA polymerase II and subsequent synthesis of, for example, inflammatory mediators and factors that influence the apoptotic process; including apoptosis of granulocytes such as neutrophils and eosinophils. Successful resolution of inflammation and restoration o

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Cyclin-Dependent Kinase (CDK) Inhibitors978-1-4939-2926-9Series ISSN 1064-3745 Series E-ISSN 1940-6029

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