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Titlebook: Cyclin-Dependent Kinase (CDK) Inhibitors; Methods and Protocol Mar Orzáez,Mónica Sancho Medina,Enrique Pérez-Payá Book 2016 Springer Scienc

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书目名称Cyclin-Dependent Kinase (CDK) Inhibitors
副标题Methods and Protocol
编辑Mar Orzáez,Mónica Sancho Medina,Enrique Pérez-Payá
视频video
概述Includes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts
丛书名称Methods in Molecular Biology
图书封面Titlebook: Cyclin-Dependent Kinase (CDK) Inhibitors; Methods and Protocol Mar Orzáez,Mónica Sancho Medina,Enrique Pérez-Payá Book 2016 Springer Scienc
描述.This volume contains a collection of relevant information for drug discovery in cell cycle research. Protocols to develop screening assays or to identify novel CDK inhibitors are discussed in the first part of the book. The second part of the book describes elaborate procedures to evaluate activity and mechanism of action of new and already identified CDK inhibitors. The third part of the book talks about protocols to evaluate metabolomics changes associated to inhibitor treatment. Drug delivery strategies focused on nanoparticle development to provide alternative internalization systems for increasing inhibitor efficacy are also described. Written in the highly successful .Methods in Molecular Biology .series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls..Authoritative and thorough, .Cyclin-Dependent Kinase (CDK) Inhibitors: Methods and Protocols. is a useful tool for scientists interested in this research field..
出版日期Book 2016
关键词CDK Inhibitor Proteins; CDK/Cyclin Pairs; Cell Culture; Cyclin-Dependent Kinase; Eukaryotic Cells
版次1
doihttps://doi.org/10.1007/978-1-4939-2926-9
isbn_softcover978-1-4939-4368-5
isbn_ebook978-1-4939-2926-9Series ISSN 1064-3745 Series E-ISSN 1940-6029
issn_series 1064-3745
copyrightSpringer Science+Business Media, LLC 2016
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Models for the Study of the Cross Talk Between Inflammation and Cell Cycle, and their inhibitors in granulocytes and particularly the role of CDKs in the apoptosis pathway. This can be performed in vitro by isolation and use of primary granulocytes and in vivo using animal models of inflammatory disease in rodents and zebrafish. Some of the methods described here to assess
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M. A. Habeeb Muhammed,Thalappil Pradeepstablished that Cdk1 is the only Cdk that is both essential and sufficient for driving the resumption of meiosis during mouse oocyte maturation. These genetic studies suggest a minimal-essential cell cycle model in which Cdk1 is the central regulator of cell cycle progression. Cdk1 can compensate fo
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Tanzeela N. Raja,Albert M. Brouwer and their inhibitors in granulocytes and particularly the role of CDKs in the apoptosis pathway. This can be performed in vitro by isolation and use of primary granulocytes and in vivo using animal models of inflammatory disease in rodents and zebrafish. Some of the methods described here to assess
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