Titlebook: Current Topics in Clinical Radiobiology of Tumors; Hans-Peter Beck-Bornholdt Book 1993 Springer-Verlag Berlin Heidelberg 1993 DNA.Onkologi

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The Influence of the Size of Dose on the Repair Kinetics of X-ray-Induced DNA Strand Breaks StudiedAfter ionizing irradiation the loss of proliferative capacity is caused by damage induced within the genetic material (M. and B. 1963a, b; B. and O. 1970; M. 1970). Among the various types of damage induced, DNA strand breaks and base damage are regarded as the critical lesions leading to cell death (W. 1985; F.-S. 1989).

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Current Topics in Clinical Radiobiology of Tumors978-3-642-84918-3Series ISSN 0942-5373 Series E-ISSN 2197-4187

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P. Criel,R. Caspeele,S. Matthys,L. Taerwe analogy, if tumor clonogens proliferate appreciably during treatment, it is obvious that cure would be easier if the total number of clonogens to be sterilized were limited by shortening the overall treatment time. The way to accomplish this, i.e., shortening of the overall time by the strategy termed ., is the subject of this chapter.

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https://doi.org/10.1007/978-3-319-47886-9roblems hamper the interpretation of the clinical studies published so far, and the magnitude of the time factor remains controversial at the time of writing. The aim of this chapter is to identify a number of these problems and to review critically our current knowledge of the time factor for human tumors.

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Time-Dose Relationships for Human Tumors: Estimation from Nonrandomized Studies,roblems hamper the interpretation of the clinical studies published so far, and the magnitude of the time factor remains controversial at the time of writing. The aim of this chapter is to identify a number of these problems and to review critically our current knowledge of the time factor for human tumors.

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https://doi.org/10.1007/978-3-319-50361-5rinkage. Accompanying radical or definitive treatment is the risk of normal tissue damage and physiological alterations. There is a narrow dose range that leads to tolerable acute and chronic side-effects while maximizing the potential for locoregional control. (C. et al. 1985; P. and B. 1987; D.V. et al. 1989)

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