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Titlebook: Crystallographic and Modeling Methods in Molecular Design; Charles E. Bugg,Steven E. Ealick Book 1990 Springer-Verlag New York, Inc. 1990

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书目名称Crystallographic and Modeling Methods in Molecular Design
编辑Charles E. Bugg,Steven E. Ealick
视频video
图书封面Titlebook: Crystallographic and Modeling Methods in Molecular Design;  Charles E. Bugg,Steven E. Ealick Book 1990 Springer-Verlag New York, Inc. 1990
描述This book contains the papers that were presented at the "Crystallo­ graphic and Modeling Methods in Molecular Design Symposium" in Gulf Shores, Alabama, April 30 to May 3, 1989. During the past few years, there has been a burst of activity in this area, especially related to drug design and protein engineering projects. The purpose of the symposium and this book is to provide an up-to­ date review of the most recent experimental and theoretical approaches that are being used for molecular design. The book covers several re­ cent examples of approaches for using crystallography in conjunction with forefront modeling methods for guiding the development of en­ zyme inhibitors and of peptides and proteins with modified biological and physical properties. In addition, this book contains discussions of new approaches for combining crystallographic data and advanced computational techniques for aiding in the design of enzyme inhibitors and other compounds that bind to selected biological targets. This book is therefore of interest not only to molecular biologists and biochem­ ists, but is stimulating reading for anyone involved in structural biol­ ogy, pharmaceutical chemistry, enzymolog
出版日期Book 1990
关键词DNA; Purine; drug; drug design; protein; protein engineering; receptor; research
版次1
doihttps://doi.org/10.1007/978-1-4612-3374-9
isbn_softcover978-1-4612-7987-7
isbn_ebook978-1-4612-3374-9
copyrightSpringer-Verlag New York, Inc. 1990
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he DNA minor groove. In the latter case, two of the four AT base pairs in the ATAT stretch have low propeller twist angles, even though the DNA has a narrow minor groove. In the netropsind(CGCGATATCGCG) structure, the drug is found to occupy in two orientations equally well, suggesting a disordered
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Crystallographic and Modeling Methods in Molecular Design978-1-4612-3374-9
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,Structural Studies of Elastase-Inhibitor Complexes with ß-Lactams,phil after the azurophilic granules entraining the enzyme are discharged into phagosomes containing engulfed debris (Parmley ., 1986). Tissue damage results when enzyme inevitably leaks out of the neutrophil (and into the extracellular space) by regurgitation during phagocytosis or by cell death, fo
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The Cambridge Structural Database in Molecular Modeling: Systematic Conformational Analysis from Crn chemical substructure may well occur in several hundred of these crystal structures. It is therefore necessary to develop rapid automatic techniques by which such large datasets may be sorted into conformational subgroups. These subgroups may then be ranked in order of their population; if two or
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