Titlebook: Crystallographic and Modeling Methods in Molecular Design; Charles E. Bugg,Steven E. Ealick Book 1990 Springer-Verlag New York, Inc. 1990

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Book 1990r aiding in the design of enzyme inhibitors and other compounds that bind to selected biological targets. This book is therefore of interest not only to molecular biologists and biochem­ ists, but is stimulating reading for anyone involved in structural biol­ ogy, pharmaceutical chemistry, enzymolog

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Take All My Wealth and Let My Body Go,omolecules. Molecular motion is modeled with classical mechanics, using a simple forcefield in which the potential energy is calculated as a sum of terms each of which depends on the coordinates of only a few atoms. Solvation is represented most accurately by including in the sample sufficient solvent molecules to entirely envelop the solute.

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978-1-4612-7987-7Springer-Verlag New York, Inc. 1990

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Take All My Wealth and Let My Body Go,The advent of directed mutagenesis has made it possible to alter protein structures at will. For the first time it is possible to design and to introduce modifications into a protein that are intended to change its behavior in predictable ways.

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Crystallographic and Genetic Approaches Toward the Design of Proteins of Enhanced Thermostability,The advent of directed mutagenesis has made it possible to alter protein structures at will. For the first time it is possible to design and to introduce modifications into a protein that are intended to change its behavior in predictable ways.