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Titlebook: Corynebacterium diphtheriae and Related Toxigenic Species; Genomics, Pathogenic Andreas Burkovski Book 2014 Springer Science+Business Media

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Comparative Genomics and Pathogenicity Islands of ,, ,, and ,,e complete genome sequences of six . isolates from various sources greatly extended the knowledge of virulence factors and indicated that this species is equipped with a distinct gene set promoting its survival under unfavorable environmental conditions encountered in the mammalian host.
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Detection Methods for Laboratory Diagnosis of Diphtheria,tially toxigenic . species from growing colonies. Finally, molecular typing techniques may be applied to explore the clonal relatedness of clinical isolates and their potential routes of transmission. The most relevant laboratory procedures fulfilling these requirements (microbiological culture, con
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Molecular Genetic Tools for Research in ,,er species. The vast expansion of tools available to characterize the pathogenic mechanisms of . has been a boon to researchers; resulting in the identification of new virulence factors, including pili and a heme oxygenase, in a species that has been studied in laboratories for more than 100 years.
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Diphtheria and its Etiological Agents,radigm of an infectious disease. According to Koch’s postulates . was isolated by Klebs and Loeffler from infected patients, grown in pure culture and used to re-infect guinea pigs as test animals. Loeffler also recognized that the bacterium predominantly colonizes the nasopharyngeal cavity and, bas
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