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Titlebook: Contraceptive Steroids; Pharmacology and Saf A. T. Gregoire,Richard P. Blye Book 1986 Springer Science+Business Media New York 1986 Lipopro

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发表于 2025-3-21 19:23:38 | 显示全部楼层 |阅读模式
书目名称Contraceptive Steroids
副标题Pharmacology and Saf
编辑A. T. Gregoire,Richard P. Blye
视频video
丛书名称The Plenum Behavior Therapy Series
图书封面Titlebook: Contraceptive Steroids; Pharmacology and Saf A. T. Gregoire,Richard P. Blye Book 1986 Springer Science+Business Media New York 1986 Lipopro
描述One of the United States Food and Drug Administration‘s most difficult tasks is the assessment of risk-benefit ratios for a broad spectrum of therapeutic and prophylactic drugs. Furthermore, it is now widely recog­ nized that no drug, chemical or even natural substance is completely devoid of risk. Nowhere has this issue been the subject of more controversy than with steroidal contraceptive drugs. Regulated as a special class of products because of their prophylactic use in healthy individuals for prevention of pregnancy rather than for treatment of disease, steroid contraceptives drugs undergo more extensive animal safety tests than any other pharmaceutical agent. This view also contemplates the availability of alternative contraceptive measures posing fewer risks, but the use of less effective methods must take into consideration the hazards associated with pregnancy itself. In April 1983, the Food and Drug Administration and the National Insti­ tutes of Health in cooperation with the World Health Organization, the Population Council, and the Agency for International Development sponsored a three-day workshop to evaluate current guidelines for preclinical safety studies of contra
出版日期Book 1986
关键词Lipoprotein; World Health Organization; assessment; drug; kinetics; lipide; metabolism; pharmacokinetics; ph
版次1
doihttps://doi.org/10.1007/978-1-4613-2241-2
isbn_softcover978-1-4612-9313-2
isbn_ebook978-1-4613-2241-2
copyrightSpringer Science+Business Media New York 1986
The information of publication is updating

书目名称Contraceptive Steroids影响因子(影响力)




书目名称Contraceptive Steroids影响因子(影响力)学科排名




书目名称Contraceptive Steroids网络公开度




书目名称Contraceptive Steroids网络公开度学科排名




书目名称Contraceptive Steroids被引频次




书目名称Contraceptive Steroids被引频次学科排名




书目名称Contraceptive Steroids年度引用




书目名称Contraceptive Steroids年度引用学科排名




书目名称Contraceptive Steroids读者反馈




书目名称Contraceptive Steroids读者反馈学科排名




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A Twenty Year Summary of FDA Animal Safety Testing of Contraceptive Steroids was implemented. That approach included a formalized investigational new drug application. As part of that program there were suggestions made that certain preclinical tests be performed before the Phase I studies of the IND could be initiated.
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Willibald Erlacher,Barbara Lesjakt, estrogens may also be toxic substances under certain circumstances. The fine line between normal physiological function and toxicological outcome has made testing of such compounds a difficult task. The purpose of this paper is to relate the normal physiological actions of estrogens to their toxicological assessment.
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Spielregeln im intelligenten Wohnumfelde healthy people. As such they must, in addition to assured efficacy rates, have high levels of safety. In recent years, particular attention has been devoted to the systemic drugs and some thirty years of accumulated experience is now available on the steroidal contraceptives used by women.
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Kai-Uwe Hellmann,Thorsten Raabe was implemented. That approach included a formalized investigational new drug application. As part of that program there were suggestions made that certain preclinical tests be performed before the Phase I studies of the IND could be initiated.
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Roland T. Mittermeir,Junichi Azumae drugs in man has been obtained only in recent years, appears limited and, in many aspects, is quite inadequate. A major obstacle used to be the lack of reliable radioimmunoassays (RIAs) to determine the minute concentrations of contraceptive steroids in serum or plasma. This problem has been solve
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Spielregeln im intelligenten Wohnumfeldism is that of the synthesis of glucuronide conjugates, which is an important metabolic pathway in humans and many other species, whereas in the cat this pathway is of little importance due to a deficiency of glucuronyl transferase. Even when there are no enzyme deficiencies, there are marked variat
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Jan-Hendrik Passoth,Matthias Wieserptive steroid formulations. It was anticipated that large doses administered for relatively short periods might be predictive of toxicological effects produced by smaller doses administered over many years, analogous to the predictive value of the cumulative effect of small doses of ionizing radiati
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