Titlebook: Contraceptive Steroids; Pharmacology and Saf A. T. Gregoire,Richard P. Blye Book 1986 Springer Science+Business Media New York 1986 Lipopro

Bph773

Oral Contraceptives and the Occurrence of Diseasel contraceptives (OCs) on the health of women. These studies have shown that, in addition to preventing unwanted pregnancy, OCs influence the occurrence of various diseases. For some of these diseases the influence is beneficial, while for others it is adverse. During the 1960s to the mid-1970s, res

小丑

Pharmacokinetics of Contraceptive Steroids in Humanse drugs in man has been obtained only in recent years, appears limited and, in many aspects, is quite inadequate. A major obstacle used to be the lack of reliable radioimmunoassays (RIAs) to determine the minute concentrations of contraceptive steroids in serum or plasma. This problem has been solve

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Species Differences in Metabolism of Contraceptive Steroidsism is that of the synthesis of glucuronide conjugates, which is an important metabolic pathway in humans and many other species, whereas in the cat this pathway is of little importance due to a deficiency of glucuronyl transferase. Even when there are no enzyme deficiencies, there are marked variat

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FATAL

Hepatotoxicity of Oral Contraceptives lead to a variety of diseases that mimic those related to diverse etiologies.. The adverse effects of OCs are most conveniently classified into those affecting the bile excretory system, vessels of the liver or hepatocytes; the latter are mainly hyperplastic and neoplastic processes. Miscellaneous

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New Steroidal Contraceptives, Implications for Toxicological Modelsble pressure of time. Extensive clinical trials were going on in several countries and the compounds worked very well. It was easily predicted that this new method of contraception would rapidly be accepted by a large number of the female population. However, the biochemical mechanisms by which the

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Morphine

An Assessment of the Toxicological and Carcinogenic Hazards of Contraceptive Steroidsrwise there will be severe economic hardship amd famine. Against this background, those of us concerned with the safety evaluation of contraceptive methods must ensure that the advice we give is relevant to the balance of hazards and benefits. Toxicologists have made assumptions that have nothing to