Titlebook: Conjugation and Deconjugation of Ubiquitin Family Modifiers; Marcus Groettrup Book 2010 Landes Bioscience and Springer Science+Business Me

爱花花儿愤怒

Regulatory Functions of Ubiquitin and SUMO in DNA Repair Pathways,n and SUMO are particularly important in the control of the DNA damage response network, which coordinates a set of DNA repair pathways and allows cells to cope with different types of genotoxic stress. In this chapter we will illustrate some key functions of ubiquitin and SUMO in the control of selected DNA repair pathways.

MURKY

Identification and Validation of ISG15 Target Proteins,mately 15 interferon-induced proteins. This chapter provides an overview of the target identification process and the validation of these targets. We also discuss the limited number of examples where the biochemical effect of ISG15 conjugation on target proteins has been characterized.

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Book 2010UFD 4 10 of Cdc48. 18 30 of Ufd2. COFACTORS 47 23 13 47 47 47 72 15 15 and of Spt23 p90. Ufd2 and Cdc48. In C. elegans 74 16 75 75 76 76 Ufd2 25 54 54 7 56 p47 7 7 80 30 30 81 82 82 but and CD3 26 DUB COFACTORS 30 UFD3 OTU1 4 Cdc48 30 4 OLE1. 15 27 87 REFERENCES 30 REGULATION OF UBIQUITIN MONOUBIQUI

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Control of Ubiquitin Conjugation by Cdc48 and Its Cofactors,olytic pathways. The diverse cellular tasks of Cdc48 are controlled by a large number of cofactors. Substrate-recruiting cofactors mediate the specific recognition of ubiquitylated target proteins, whereas substrate-processing cofactors often exhibit ubiquitin ligase or deubiquitylating activities t

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Regulation of Ubiquitin Receptors by Coupled Monoubiquitination,eins with Ubiquitin (Ub). Ub-receptors, i.e., effector proteins carrying Ub-binding domains (UBDs), recognize ubiquitinated proteins and trigger specific cellular responses. The activity of Ub-receptors is controlled by “coupled monoubiquitination” which provides an efficient switch from an active t

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Control of Cullin-Ring Ubiquitin Ligase Activity by Nedd8,nzymes regulate cell biology by conjugating ubiquitin onto target proteins that are involved in a multitude of processes. In most cases this leads to degradation of the target, but in some cases CRL-dependent ubiquitination acts as a switch to activate or repress target function. The ubiquitin ligas

UTTER

Control of Deneddylation by the COP9 Signalosome,entiation. One of the best studied crosstalks between Ub family modifiers is the stimulation of ubiquitination by Nedd8 (neural precursor cell expressed developmentally down regulated 8) modification. The neddylation-deneddylation pathway controls the selective ubiquitination of important cellular r

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,Ubiquitin Conjugation and Deconjugation in NF-κB Signaling,impact of the covalent protein modifier ubiquitin on signal transduction. The discovery in the early 1990s that degradation of cytosolic NF-κB inhibitors (IκBs) is mediated by the ubiquitin proteasome system (UPS) was the first example for a direct involvement of ubiquitination in cellular signaling