Titlebook: Conjugation and Deconjugation of Ubiquitin Family Modifiers; Marcus Groettrup Book 2010 Landes Bioscience and Springer Science+Business Me

凹槽

丰富

Reorientation and Controversy (1895–1899)biquitination and the different layers of deubiquitinase specificity. The individual deubiquitinase families are discussed with a focus on structure, regulation and specificity features for selected enzymes.

Expostulate

同位素

staging

Reorientation and Controversy (1895–1899)lved in the regulation of p53 ubiquitination but will focus on the enzymes and components of the respective conjugation systems that have been implicated in p53 modification and how the respective modifications (ubiquitin, SUMO-1, NED 8) may impinge on p53 activity.

女歌星

maudtin

https://doi.org/10.1007/978-0-387-75688-2gases that specifically recognize SUMO-modified proteins have been discovered in species ranging from yeasts to humans. This chapter summarizes what is known about these ligases and their role in controlling sumoylated proteins.

deface

Conjugation and Deconjugation of Ubiquitin Family Modifiers

天真

Essential

https://doi.org/10.1007/978-0-387-75688-2ty of specific proteases to mediate these cellular events is presented. In addition, we examine cases in which aberrant SUMO protease expression affects normal embryonic development, carcinogenesis and the onset of additional pathophysiological conditions.