Titlebook: Concepts and Principles of Pharmacology; 100 Years of the Han James E. Barrett,Clive P. Page,Martin C. Michel Book 2019 Springer Nature Swi

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Unification of Hypergraph ,-Termsally, physiologically and/or medically relevant information, however, remains challenging. In contrast, mechanistic computational modelling provides a means to formalise and dissect mechanisms governing the behaviour of complex systems. However, its application often is limited due to the lack of re

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Saeid Hanifehnezhad,Ardeshir Dolatiassess their health or other status and their responses to experimental interventions. Metabonomics is thus widely used in disease diagnosis and in understanding responses to therapies such as drug administration. Pharmacometabonomics, also known as pharmacometabolomics, is a related methodology but

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Mohammad Reza Mousavi,Jiří Sgalll practice. Recent advances in multi-“omics” techniques have dramatically improved our understanding of the constituents of the microbiome and their functions. The implications of this research for human health, including microbiome links to obesity, drug metabolism, neurological diseases, cancer, a

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Topics in Theoretical and Applied Statisticsby Austin Bradford Hill. This standard has produced enormous amounts of high-quality evidence, resulting in evidence-based clinical guidelines for physicians. However, the current trial paradigm needs to evolve because of the ongoing decrease of the incidence of hard endpoints and spiraling trial co

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Barbara Cafarelli,Corrado Crocettaase the placebo effect in randomized placebo-controlled trials. These factors can be subdivided into four groups, and while not all factors are effective in every study and under all clinical conditions, they show on the whole that – even under the ideal condition of drug therapy, where blinded plac

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Lidia Rivoli,Rosanna Verde,Antonio Irpinonical trials (RCT), comparing them to placebo or to existing drugs. However, RCT are by nature limited in their extent, and the often stringent inclusion and exclusion criteria destined to provide for homogeneous study populations reduce the generalizability of RCT results..The post-authorization ev