Titlebook: Computational Methods for SNPs and Haplotype Inference; DIMACS/RECOMB Satell Sorin Istrail,Michael Waterman,Andrew Clark Conference proceed

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How Does Choice of Polymorphism Influence Estimation of LD and Mapping? on studies of the NIDDM1 region of 2qter and a region on chromosome 15 including CYP19 in which we have made a systematic examination of the effects of this type of polymorphism choice. While our conclusions are clearly limited because we have studied only these two regions, our results suggest tha

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Haplotype Inference and Haplotype Informationpe information contributes to linkage disequilibrium (LD) mapping and whether an in silico haplotype construction preceding the LD analysis can help. For simple disease gene mapping our conclusions are as follows: (a) if a proper statistical model is employed, the loss of haplotype information for e

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Haplotype Inference and Its Application in Linkage Disequilibrium Mappingto its potential value in disease gene identification and in pharmacogenomics. Because molecular haplotyping methods remain too costly to be used on a regular basis, statistical techniques for haplotype inference have emerged as the most time- and cost-efficient approach. This chapter explains the s

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Inferring Piecewise Ancestral History from Haploid Sequencesarching for genetic predictors of human disease. The use of haplotype structure is based on the premise that genetic variations that are physically close on the genome will often be predictive of one another due to their frequent descent intact through recent evolution. Understanding these correlati

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Haplotype Blocks in Small Populationsof recombination, it is first necessary to understand the effects of population history and demography on the survival of ancestral chromosome segments in the absence of these phenomena. In this paper, we present results on the mean and variance of lengths of ancestral segments and shared segments i