Titlebook: Computational Methods for SNPs and Haplotype Inference; DIMACS/RECOMB Satell Sorin Istrail,Michael Waterman,Andrew Clark Conference proceed

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书目名称Computational Methods for SNPs and Haplotype Inference读者反馈学科排名

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Kyoko Okino,Kentaro Nakamura,Hiroshi Sato21 confounded. A variety of methods including EM and Bayesian analysis have provided useful solutions for haplotype phasing of disomic genotypes. Here we provide an extension to the Bayesian approach for inferring linkage phase in trisomic samples.

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Springer Series in Materials Sciencen chromosomes from a current population. In a small population, patterns of growth and population subdivision may have a substantial impact on observed patterns of chromosome segments, and the length distributions have high variance and are heavy-tailed.

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Conference proceedings 2004Piscataway, NJ, USA, in November 2002...The book presents ten revised full papers as well as abstracts of the remaining workshop papers. All relevant current issues in computational methods for SNP and haplotype analysis and their applications to disease associations are addressed..

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https://doi.org/10.1057/9781137012104be highly accurate over regions with high linkage disequilibrium (LD). If only polymorphisms with aminor allele frequency 10.2 are analyzed and scored according to the fraction of neighbor relations correctly called, reconstructions are 95.2% accurate over entire 100-kb stretches and are 98.6% accurate within blocks of high LD.

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Code of Coordination for Corporate Taxation, each block. Our method partitions the SNPs into blocks and for each block, we predict the common haplotypes and each individual’s haplotype. We evaluate our method over biological data. Our method predicts the common haplotypes perfectly and has a very low error rate (0.47%) when taking into account the predictions for the uncommon haplotypes.