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Titlebook: Complex Carbohydrates of Nervous Tissue; Richard U. Margolis,Renée K. Margolis Book 1979 Plenum Press, New York 1979 adenosine.brain.carbo

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Glycoprotein Storage Diseases and the Mucopolysaccharidoses,ave been characterized by the isolation of a specific storage product or products and by a specific enzyme deficiency. The fundamental basis for the neurological degeneration is unknown, although recent studies (Purpura and Suzuki, 1976) indicate that secondary neuronal membrane changes (meganeurite
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[Acetyl-CoA carboxylase] kinase,and Gommi, 1965; Vaccari .., 1971), and there is evidence that the cholera toxin receptor involves a ganglioside (Cuatrecasas, 1973; Holmgren .., 1973; Van Heyningen W. E., .., 1971; Van Heyningen, S., 1974). The nicotinic acetylcholine receptor also contains carbohydrate (Meunier ., 1974; Raftery .
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[Acetyl-CoA carboxylase] kinase,n the axon. Nemiloff (1908) also described the staining of the nodal cement substance in unfixed nerves with methylene blue. Early attempts to demonstrate other ionic species at nodes of Ranvier by precipitation with heavy metals were also made (Macallum, 1905; Macallumand Menten, 1906).
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Ca2+/Calmodulin-dependent protein kinase,72) developed a specialized embedding technique and stained with silicotungstic acid to provide electron-microscopic evidence for the presence of glycoproteins in the intraperiod line of peripheral myelin, supporting Robertson’s earlier hypothesis. The first direct biochemical demonstration of glyco
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