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Titlebook: Combination Therapies 2; Biological Response Enrico Garaci,Allan L. Goldstein Book 1993 Springer Science+Business Media New York 1993 AIDS

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Thymosin α1: Chemistry, Mechanism of Action and Clinical ApplicationsThymosin α., is a 28 amino acid, 3108 molecular weight acidic peptide isolated from thymosin fraction 5 (1). Its amino acid sequence is homologous in murine, bovine and human species (2) and a chemically synthesized version (3) has shown activity similar to the native peptide in modulating T-cell maturation (1).
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Differentiating Agents and Cancer Therapy. Role of Cellular Lipid Peroxidation and its Product 4-HydNumerous experimental observations provide evidences that malignancy can be reversed by causing cancerous cells to differentiate and stop growing (1–5). This statement implies that transformation does not inevitably destroy the inherent potential for expression, under appropriate environmental conditions, of differentiated characteristics.
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https://doi.org/10.1007/978-3-319-42931-1 at the very interface between tumor and host, they may represent a strategically located target for therapeutic intervention. Interest in these cells is stimulated by the knowledge that macrophages have the potential to kill neoplastic cells including drug-resistant variants surviving conventional chemotherapy (Allavena et al 1987).
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