| 书目名称 | Clostridial Neurotoxins | | 副标题 | The Molecular Pathog | | 编辑 | Cesare Montecucco | | 视频video | | | 丛书名称 | Current Topics in Microbiology and Immunology | | 图书封面 |  | | 描述 | Tetanus has been known from the very beginning of medical literature since it was first described by Hyppocrates of Cos in the fifth century B.C. For 24 centuries it was considered a neuro logical disease until the breakthrough of CARLE and RATIONE (1884) who demonstrated its infectious etiology. Following the establishment of purified cultures of Clostridium tetani(KITASATO 1889), FABER (1890), and TIZZONI and CATIANI (1890) demon strated that the disease is actually an intoxication caused by a proteic neurotoxin. This toxin was shown by BRUSHCHETIINI (1892) to move retroaxonally and to act at the spinal cord level. Soon thereafter VAN ERMENGEN (1897) demonstrated that botu lism is also due to intoxication with a protein toxin produced by bacteria of the genus Clostridium. These bacteria and their spores and ubiquitous, and the majority of them do not produce neurotoxins. The selective advantage of producing such potent toxin is still a matter of speculation (see Popoff, this volume). The next major advance was the discovery that tetanus neurotoxin 1 can be converted by formaldehyde treatment to a nonpathogenic but still fully immunogenic form, and that this can be used success | | 出版日期 | Book 1995 | | 关键词 | Lebensmittelvergiftung; Neurotoxins; Syntaxin; Wundstarrkrampf; cell biology; exocytosis; genetics; growth; | | 版次 | 1 | | doi | https://doi.org/10.1007/978-3-642-85173-5 | | isbn_softcover | 978-3-642-85175-9 | | isbn_ebook | 978-3-642-85173-5Series ISSN 0070-217X Series E-ISSN 2196-9965 | | issn_series | 0070-217X | | copyright | The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE |
The information of publication is updating
|
|
发表于 2025-3-21 17:19:16
