Titlebook: Clinical Trials In Parkinson‘s Disease; Santiago Perez-Lloret Book 2021 Springer Science+Business Media, LLC, part of Springer Nature 2021

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Recessive

Clinical Trials for Erectile Dysfunction in Parkinson’s Diseaseents of ED in PD remain scarce, and existing studies were limited by small sample size and open-label methodology. Therefore, well-designed double-blind RCTs are required to further understand the efficacy and adverse effect profiles of these treatments in PD.

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野蛮

B. D. Tapley,A. R. Neto,B. E. Schutzutic approaches. This chapter will discuss the terminology and definition of depression, anxiety, apathy, and fatigue in PD, their differentiation from other PD- and non–PD-related symptoms, subtyping, physiological markers, as well as considerations related to the optimal outcome measures and design of clinical trials.

GLADE

https://doi.org/10.1007/978-981-10-3713-9tools to assess subjective and objective outcome measures, and the pitfalls and considerations pertaining each of these methods. Clinical trials will be reviewed to identify strengths and weaknesses, and lastly, a series of recommendations will be outlined for the design of clinical trials for constipation in Parkinson’s disease.

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Assessment of Nonmotor Symptoms in Rodent Models of Parkinson’s Diseaseimal models, although with some limitation..This chapter will provide an overview of the PD nonmotor symptoms in the most common toxin-based rodent models, highlighting their translational value for clinical investigations.

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