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Titlebook: Clinical Trials In Parkinson‘s Disease; Santiago Perez-Lloret Book 2021 Springer Science+Business Media, LLC, part of Springer Nature 2021

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发表于 2025-3-21 18:21:54 | 显示全部楼层 |阅读模式
书目名称Clinical Trials In Parkinson‘s Disease
编辑Santiago Perez-Lloret
视频video
概述Includes cutting-edge methods and protocols.Provides step-by-step detail essential for reproducible results.Contains key notes and implementation advice from the experts
丛书名称Neuromethods
图书封面Titlebook: Clinical Trials In Parkinson‘s Disease; Santiago Perez-Lloret Book 2021 Springer Science+Business Media, LLC, part of Springer Nature 2021
描述This volume looks at major clinical trials for motor and non-motor symptoms in Parkinson’s Disease (PD) and covers important aspects, including trial design, sample selection, and outcome selection. Chapters in this book discuss topics such as toxin-based rodent or genetic models of PD; clinical trials for motor symptoms, L-DOPA related motor complications, and gait disorders; clinical trials for mood disorders, troubled sleep, autonomic dysfunction; and clinical trials for disease modifying therapies. In the .Neuromethods. series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory or research center..Cutting-edge and authoritative, .Clinical Trials in Parkinson’s Disease. is a valuable resource for clinicians and researchers who want to enhance their interpretation of results from clinical trials and to design their own high-quality trials.   .
出版日期Book 2021
关键词hypotension; Sleep disorders; anxiety; Dementia; levodopa-unresponsive motor symptoms
版次1
doihttps://doi.org/10.1007/978-1-0716-0912-5
isbn_softcover978-1-0716-0914-9
isbn_ebook978-1-0716-0912-5Series ISSN 0893-2336 Series E-ISSN 1940-6045
issn_series 0893-2336
copyrightSpringer Science+Business Media, LLC, part of Springer Nature 2021
The information of publication is updating

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发表于 2025-3-21 20:29:07 | 显示全部楼层
Assessment of Nonmotor Symptoms in Rodent Models of Parkinson’s Disease (PD) neuropathology and to develop new therapeutic strategies. The toxin-based rodent models of PD offer a valuable tool as they allow to mimic many of the features of the disease, particularly motor symptoms such as akinesia and bradykinesia. Interestingly, PD nonmotor symptoms, such as neuropsych
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Genetic Models of Parkinson’s Disease The etiology of idiopathic PD, which represents most of the cases, is still unclear but seems to be multifactorial, associating environmental and/or genetic factors. The major limitation of “classical” toxin-based animal models of PD is that they do not replicate some characterizing features of the
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Clinical Trials for Disease-Modifying Agents in Parkinson’s Diseaseor this. PD is clinically and pathophysiologically heterogeneous and has relatively insidious and protracted progression. Symptomatic therapies confound measurement of the disease as well. With this complexity comes the challenge of identifying optimal study design and outcome measures for clinical
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Value and Methods of Pharmacovigilance in the Monitoring of Drug Safety in Parkinson’s Diseases a key role in evaluating drug safety and efficacy under real-world conditions of use following market authorization. Pharmacovigilance focuses mainly on adverse drug reactions (ADRs), which are unintended adverse medical events caused by an approved drug used at normal human doses for the prophyla
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