Titlebook: Clinical Epigenetics; Luke B. Hesson,Antonia L. Pritchard Book 2019 Springer Nature Singapore Pte Ltd. 2019 epigenetics.genetics.pathology

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浮雕

disorders, and include examples of epigenetic changes that can be used in diagnosis, prediction of therapeutic response, prognostication or disease monitoring. Finally, for those wishing to implement epigenetic978-981-13-8960-3978-981-13-8958-0

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Dysregulation of ,-Regulatory Elements in Cancer,mark of cancers, we will focus on the role of somatic changes in genomic DNA that lead to alterations in the control of expression in key oncogenes. Finally, this chapter will highlight some potential clinical utility of recent research in the field and emerging therapies that can be used to target

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physically alter chromatin structure but also recruit remodelling enzymes that reposition nucleosomes. This chapter describes the various histone variants and modifications that control chromatin structure and highlight how these modifications can alter transcription. These histone variants can be a

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mark of cancers, we will focus on the role of somatic changes in genomic DNA that lead to alterations in the control of expression in key oncogenes. Finally, this chapter will highlight some potential clinical utility of recent research in the field and emerging therapies that can be used to target

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M. Rehahn,W. L. Mattice,U. W. SuterCytosine methylation is an important epigenetic signalling mechanism that regulates gene expression. The presence of 5-methylcytosine (5-mC) at promoters is associated with gene silencing. In this chapter, we will describe our current understanding of

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In a clinical pathology setting, epigenetic testing is rare and underutilised. In this chapter, we describe a patient with early-onset colorectal cancer caused by a constitutional epimutation. This case study emphasises the importance of epigenetic testing when standard genetic testing has failed to identify a cause for disease predisposition.

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