Titlebook: Clinical Epigenetics; Luke B. Hesson,Antonia L. Pritchard Book 2019 Springer Nature Singapore Pte Ltd. 2019 epigenetics.genetics.pathology

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M. Rehahn,W. L. Mattice,U. W. Suter to the non-expert reader and give an account of the pivotal discoveries that have helped shape these fields. The significance of major discoveries will be explained and their impact on our understanding of epigenetic mechanisms in health and disease will be discussed.

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standing of the disease biology and testing platform limitations. As the biological basis for these rare disorders is revealed, testing approaches must encompass both genomic and epigenomic investigations to ensure that affected families are fully informed of transmission and recurrence risks.

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M. Rehahn,W. L. Mattice,U. W. Suter to the non-expert reader and give an account of the pivotal discoveries that have helped shape these fields. The significance of major discoveries will be explained and their impact on our understanding of epigenetic mechanisms in health and disease will be discussed.

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rstood to be incompatible with gene expression when found in regulatory regions including gene promoters and enhancers. Oxidized 5-methylcytosine bases, in the form of its hydroxyl, formyl and carboxyl derivatives, have been known for about 10 years. Their biological functions in development and in

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ating unit of chromatin is the nucleosome, an octamer of histone proteins wrapped around twice with DNA. Transcriptional gene regulation is largely controlled by the epigenetic regulation of the nucleosome, both through the position of the nucleosome in the DNA and chemical modifications to the hist

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