Titlebook: Chronic Myeloid Leukemia; Rüdiger Hehlmann Book 2021Latest edition The Editor(s) (if applicable) and The Author(s), under exclusive licens

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The Turbulent Environment, Then and Nowreating other causes of death as competing risks are highlighted. In the presence of competing risks, the application of both the cause-specific hazard model and the subdistribution hazard model is recommended when investigating the influence of prognostic factors on the event of interest. A detaile

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https://doi.org/10.1007/978-3-030-63875-7ee remission has become a goal of CML treatment, although, so far, it can be reached by a minority of patients. In this chapter we discuss these advances and other still open issues in CML management, analyzing some key points of the ELN 2020 recommendations.

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Die Hermeneutik der Psychopathologie,ses with imatinib therapy. Furthermore, emerging data from combination trials with second-generation TKIs suggest long-term use of IFNα may deepen molecular responses in CML patients. However, the undesirable side effects of IFNα can make this therapy difficult to deliver, and the optimal therapeuti

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Ein Zeitalter radikaler Ungewissheitlity in either male or female patients. However, and dependent on individual circumstances, it may be useful to discuss the options for fertility preservation including semen cryopreservation, ovarian or oocyte retrieval and storage and embryo cryopreservation. The TKI are teratogenic and should not

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https://doi.org/10.1007/978-3-658-20005-3dvanced-phase disease. Treatment failure mandates a switch in therapy, usually to a more potent TKI, if possible. In between optimal response and treatment failure, there is a “warning category” where outcomes are generally inferior and therapeutic decisions are more complex. Recently, the importanc

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Cytogenetics of Chronic Myeloid Leukemia (CML),d they were able to improve their preparation technique and report a series of seven patients all displaying a minute chromosome. In accordance with the Committee for the Standardization of Chromosomes, Tough and colleagues called this minute chromosome Philadelphia chromosome after the city it was